Vein Health News
The vein magazine for healthcare providers
“Since venous disease does have a strong genetic component, it is important for people to know their family history.” — Dr. Cindy Asbjornsen, Vein Healthcare Center
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Letter from the Editor
Any questions?

As a physician (and the parent of two teenagers and a tween), I ask a lot of questions. And I'm encouraged when patients (and my kids) ask me questions in return!

When a patient asks a question, it is an opportunity to educate and clear up misconceptions. It also helps me to better understand the bigger picture of their health and what their goals are for treatment. In this issue of Vein Health News, we share many of the typical questions that patients ask about their legs - or perhaps don't know to ask. Answering these questions can cast light on a diagnosis and, hopefully, lead to treatment and resolution.

Our second feature article explores the topic of lymphedema and swelling. There are many reasons for lymphatic overload, including venous insufficiency, but I want to focus on treatment. There is no cure for lymphedema, but the earlier you can diagnose it, the easier it is to manage the swelling and help patients live comfortably with the condition.

Certified Lymphedema Therapists (CLT) are trained to perform Complete Decongestive Therapy (CDT), a program that combines different treatment modalities, such as bandaging, compression garments, manual lymphatic drainage, skin care, education, and exercise. Physical therapists and occupational therapists are among the most common CLTs, though many other medical fields can be accepted for training, including registered nurses, doctors, chiropractors, nurse practitioners, and physician assistants.

Currently, medical centers dedicated to lymphedema treatment are often limited to serving oncological patients. As we learn more about the prevalence of the condition, however, I envision a time when many more offices and clinics open to help people suffering from lymphedema, whatever the cause. When swelling is reduced, all other treatment becomes more possible.

Have you encountered patients with swelling? Is it lymphatic or venous in nature? Or both? So many questions! If you have any questions for me, please contact me. I look forward to it.

- Dr. Cindy Asbjornsen, D.O., FAVLS, RPhS, ABVLM, FAVLS
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Cover Story

Do I Have Venous Disease? Q&A with Dr. Cindy Asbjornsen

By Jennifer Boggs | Feature

Vein, or venous, disease is very common among the U.S. population. According to the American Vein & Lymphatic Society (AVLS), 80 million Americans struggle with some form of vein disorder.

Often, those experiencing symptoms of venous disease live with their symptoms because it is undiagnosed, or the source of their symptoms has been left untreated. Even if a patient is experiencing only mild symptoms of venous disease, as the disease progresses it can lead to chronic venous insufficiency and result in serious medical complications.

What follows is an interview with Dr. Cindy Asbjornsen, founder of the Vein Healthcare Center and board certified vein specialist. Dr. Asbjornsen answers vein health questions most commonly asked by patients. While this interview is not intended to be a substitute for professional medical advice, diagnosis, or treatment, it can serve to clear up misconceptions about vein disease and the best ways to treat it.

A: Legs that feel heavy or fatigued are common indicators of venous insufficiency. Legs can feel tired at the end of the day or after long periods of standing because of an increase in pressure that results from blood pooling in the legs when the blood cannot be efficiently returned upstream to the heart. Treating the veins causing this insufficiency can eliminate discomfort and restore quality of life.

Getting specific: If your legs are tired after being on them all day, really pay attention to what you're feeling. Don't dismiss the discomfort as "normal after a long day." There may be a big difference between what you're used to and what your legs could feel like.

A: If you experience tired or heavy-feeling legs, try elevating them for three minutes. Venous symptoms usually improve when the legs are raised, and the relief is a good indication that the fatigue you are experiencing is a symptom of venous insufficiency.

Getting specific: Leg elevation means raising the legs above heart level. The ideal position is to lie on a couch with your head, back, and torso on the cushions and feet up on the armrest, so feet are at a slight angle higher than the heart. Lying down with the legs resting on three or four pillows can also work well.

A: This is called dependent edema, the medical term for swelling. If you experience swelling in your leg that is better in the morning, improves after you have been lying down, and/or gets worse as the day progresses, it is an indication that blood is not being properly returned to the heart possibly due to a faulty valve in the vein. Treating veins that are causing the insufficiency can eliminate leg swelling.

Getting specific: Abnormal buildup of fluid in the ankles, feet, and legs can be a result of veins in the legs that cannot properly pump blood back to the heart, as well as an indication of a venous disorder. There are many underlying causes of edema, however. Lymphedema is a condition that occurs when the lymphatic system is damaged or blocked and protein-rich fluid builds up in soft body tissues causing swelling. Phlebolymphedema is a condition of mixed venous and lymphatic insufficiency and affects mostly the legs.

A: They may appear as short fine lines, clusters, or in a spider web shape and can be a source of embarrassment and self-consciousness. In some cases, they're also painful. Telangiectasia or "spider veins" are an indication of early stage venous disease, and treating them not only can improve appearance but can help stop the progression of venous disease.

Getting specific: Vein health is a continuum, so while spider veins may appear minimal, there could be a larger vein with issues underneath. What you see just beneath the skin may actually be the tip of the iceberg of vein disease.

A: Veins that protrude from the skin in the legs are varicose veins, and they are an indication of progression of early venous insufficiency. They may or may not be painful, and, like spider veins, may cause embarrassment due to their appearance. Left untreated, they can lead to increased venous symptoms and worsening appearance. In most cases, if the vein is bulging, it has a connection to the deep system.

Getting specific: Bulging or protruding veins are visual - and, if they hurt, physical - clues that something is going on within your venous system. In the past, visible veins have been dismissed as "merely cosmetic," or "part of getting old." Neither is true; varicose veins are a medical issue that can be treated.

A: Those experiencing unpleasant or urgent sensations in the leg, or those who have been diagnosed with restless leg syndrome (RLS), may be experiencing symptoms of venous insufficiency. When restless leg occurs in conjunction with vein disorders, vein treatment can cause relief of symptoms and eliminate the need for medications.

Getting specific: About 40 percent of people with RLS have problems with their veins, but the relationship between RLS and venous disease is not yet fully understood. Research shows that there is high correlation of patients who see their RLS resolve when they receive venous treatment. Research findings and anecdotal evidence suggest that the patients who are evaluated for restless legs syndrome could also benefit from an evaluation for possible vein disease.

A: There are many causes of cramping; hydration status is often the issue. However, leg cramps can often go undiagnosed as venous insufficiency. Cramping can occur as a result of standing or being still for long periods of time, or it can occur while lying in bed at night as a result of blood that has built up in the leg over the course of a day. The pain can be mild in some cases, and in others it can cause severe pain and loss of sleep. Treating the faulty valve at the source can eliminate cramps and restore quality of life.

Getting specific: Some patients with venous disease may suffer from leg cramps but without noticeable signs of varicose veins or spider veins. An ultrasound evaluation performed by a qualified sonographer working with a credentialed vein specialist can detect venous reflux.

A: Venous disease can cause general leg symptoms that do not manifest as aching or pain, but rather as itching or tingling. These sensations can occur after standing, or they can happen at night while in bed. This is often an indication of vein insufficiency, and it can be evidence of a disorder that is beginning to progress. Treatment can stop discomfort by treating the insufficiency at its source.

Getting specific: Varicose veins itch because of a condition called stasis dermatitis, also known as varicose eczema. Symptoms of stasis dermatitis can include swelling, redness, and painful skin, which may be weeping and crusty. These changes will usually start low, affecting the ankles first and then extending to the calf. Additional symptoms may develop, such as purple or red sores, or skin that is dry, cracked, shiny, and itchy.

A: If you notice redness around the ankles, or find that your skin has become harder or thicker in the lower leg, you are likely experiencing a common symptom of venous disease. These changes can be mild, or they can cause pain and involve larger areas of the skin. Other skin changes, such as stasis dermatitis, cellulitis, or dry or scaly skin, can be signs of advanced venous disease.

Getting specific: A common discoloration of the lower leg, ankle or foot are brown or rusty-colored "patches" or "stains," which are known as hemosiderin deposits. When vein valves fail, regurgitated blood forces red blood cells out of the capillaries. When the red blood cells break down, the hemoglobin releases iron and is stored as hemosiderin in tissues beneath the skin, which causes the staining. Hemosiderin staining can be signs of advanced venous disease.

A: Open wounds or wounds that just won't heal - on the lower leg or ankle can be a sign that venous disease has reached an advanced stage. There are three common classes of ulcers: diabetic, arterial, and venous. Of the three types, venous is the most common. Venous ulcers usually occur on the lower leg below the knee. They can be caused by venous insufficiency or by a wound that has been exacerbated by venous insufficiency. If you have skin breakdown or infection due to ulceration, you should visit your doctor immediately.

Getting specific: Because venous disease is progressive, venous reflux can often lead to additional valve failure and, as a result, the pooling of blood can affect a larger area. When blood leaks into the tissue of the skin it can cause swelling and damage to the tissue. At this point, the skin on the lower limbs has really begun to break down. Ulcers may be painful or itchy and often require constant care and dressing. Because ulcers do not heal on their own, they can have a significant impact on quality of life.

A: Venous disease has a strong genetic component. If someone in your family has experienced vein disorders or has visible veins on their leg, your risk of the disease is much higher. Even if you are not experiencing symptoms, a screening can evaluate the condition of your venous system and help you begin lifestyle changes that can prevent symptoms from occurring.

Getting specific: If one parent has vein disease, you have about a 33% chance of also developing vein problems. If both of your parents have vein issues, then your chances go up to 90 percent. Since venous disease does have a strong genetic component, it is important for people to know their family history.

A: Pregnancy can cause swelling and increase risk factors for venous disorders. The buildup of fluid in the ankles, feet, and legs can be a result of veins in the legs that cannot properly pump blood back to the heart. Some women find that their swollen legs - and varicose veins - go away, or improve, after labor, while others continue to suffer with them.

Getting specific: About forty percent of pregnant women are likely to develop varicose veins. During pregnancy, a combination of hormonal changes (specifically, greater amounts of estrogen and progesterone) and increased pressure on the abdomen can cause varicose veins. If there is a strong family history of vein issues, woman might consider seeking treatment for problematic veins before their first pregnancy. Someone who experienced vein discomfort during a pregnancy, may want to consider treatment before her next pregnancy, as the problems may worsen.

The second and third trimester may also carry some risk of developing varicose veins. The volume of blood in a healthy woman increases to about 50% more than before the pregnancy, with the largest increase in the second trimester. With more volume to move, all of the blood vessels are under increased stress. In this final trimester, the uterus continues to expand and put pressure on the veins in the abdominal region, restricting venous return by a physiologic barrier. The most damage, however, seems to happen in the first trimester.

If pregnant patients - especially those with a family history of venous disease - pay attention to their vein health, it can go a long way toward treating, or even preventing, a problem that has numerous solutions.

Here are some things you can suggest to patients to help decrease or prevent varicose veins during pregnancy are:

  • Wear graduated compression stockings, especially in the first trimester.
  • Exercise often; even a brisk walk will help circulation and reduce symptoms.
  • Frequently pump the foot (heel to toe), even if on bed rest.
  • Avoid tight clothes or high-heeled shoes.
  • Gain only as much weight as recommended by the obstetrician
  • Take a pre-natal vitamin daily.
Talk to an expert

Sometimes venous disease is very obvious. Bulging, twisty veins that wrap around your legs is one manifestation. Purple spidery veins on the backs of your thighs may be another. But there are other, subtle clues that veins may not be working as well as they should.

Whatever signs of vein disease you may observe, it's best not to ignore them. Waiting for the issues to go away on their own may actually make them worse as time goes on. An evaluation by a trained vein specialist will help patients understand how their veins are working.

It is important that patients experiencing symptoms, requesting evaluation, or inquiring about cosmetic vein removal seek help from a board certified vein specialist who can assess the source of the insufficiency and provide professional medical care. While the presence of vein insufficiency can often be diagnosed in the superficial vein, only comprehensive examination by a phlebologist can identify the source of insufficiency. The use of venous ultrasound is critical for the detection of venous insufficiency at its source. Ultrasound mapping and interpretation by a highly skilled vascular sonographer is paramount to receiving an accurate diagnosis.

Treatment by uncertified providers, or treatment of cosmetic concerns without taking overall health and venous health of the patient into account, is a common consequence of the ease of today's modern treatment. Without a full understanding of both vein health and pathology, wrong treatment options can cause more damage to the venous system and subsequently unhappy patients. Thus, it is critical that patients be treated by a certified phlebologist who can provide professional medical care and is committed to their overall health.


Lymphedema

Lymphedema: System Overload?

By Benjamin Lee

The human body needs lymph. The clear-to-white fluid contains white blood cells, especially lymphocytes, the cells that attack virus in the blood. Lymph circulates throughout the body and acts as a filter against microbes, organic wastes, and other debris. It helps the body to fight infection, but when there is an excess of lymph, it can overload the system. The result is a clinical condition called lymphedema. (Edema means "swelling," so the term literally means "swelling due to the increased collection of lymphatic fluid.")

Primary and secondary lymphedema

Lymphedema occurs when the lymphatic system is damaged or blocked and the protein-rich lymphatic fluid builds up in soft body tissues causing swelling. Clinically, this condition is classified as primary and secondary.

Primary lymphedema is caused by the abnormal development of the lymph system, such as congenital malformation; infection or injury in utero; or a side effect to a developmental disorder of the lymphatics.

Secondary lymphedema, a more common condition, is caused by damage to the lymph system any time after birth, or by removal of lymph nodes because of injury, trauma, infection of the lymphatics, or cancer biopsy. In fact, lymphedema is a common problem that may be caused by cancer and cancer treatment, although the patient may not notice any swelling until months or years after treatment.

In a 2018 study published in the Journal of Vascular Surgery: Venous and Lymphatic Disorders, researchers examined more than 27,000 de-identified records in a database of patients diagnosed with lymphedema. The study found that breast cancer was the most common disease associated with lymphedema, accounting for a third of the patients, while advanced venous disease was the second most common cause at 10 percent.

"All swelling is lymphatic overload"

Andrea Brennan, OTD, OTR/L, CI-CS, WCC and Founder & CEO, Brennan School of Innovative Lymphatic Studies has been working on lymphedema treatment exclusively since 1996. In 2012, she received her clinical doctorate practicing in lymphedema management and administration, and in 2016, she became an international instructor of the Keslee-Smith International Treatment Method.

Brennan stated that all swelling, no matter the cause, is lymphatic overload. This is a different approach to lymphedema due to the relatively recent findings about interstitium, a layer of macroscopic fluid-filled compartments surrounded by collagen that can be found throughout the body.

In 2015, two researchers, Dr. David Carr-Locke and Dr. Petros Benias from Mount Sinai-Beth Israel Medical Center, discovered the fluid-filled cavities while using a relatively new technology called a "probe-based confocal laser endomicroscopy," or pCLE, which allows a microscopic view of living tissue.

The results of further study were published in 2018 in the Scientific Reports journal. In "Structure and Distribution of an Unrecognized Interstitium in Human Tissues," the authors propose that the anatomical concepts of the submucosa, dermis, fascia, and vascular adventitia be revised; rather than being densely-packed barrier-like walls of collagen, they are fluid-filled interstitial spaces.

What does the recent discovery of interstitium's role suggest about the nature of lymphedema?

The venous and the lymphatic systems work in concert to remove excess fluid from the body's tissues if it builds up, but it was previously believed that when there was a problem with edema that the venous system absorbed most of the excess fluid. Now because of the current research, we understand that if there is increased fluid in the interstitium, it's actually not being re-absorbed on the venous side — that all fluid in the interstitium has to be absorbed by the lymphatic system. If the patient is suffering from venous insufficiency, the leakage from the capillary combined with additional fluid due to venous reflux creates increased hydrostatic pressure and thus overloads the lymphatic system.

"The combination of impaired veins and high-protein edema lays the groundwork for a wound," said Brennan. "You cannot treat one without the other. Wherever you have a vein, you have a lymph. They're connected."

Signs and symptoms

The main sign of lymphedema is distal swelling in the extremities including the arms, hands, legs, feet, although proximal swelling can also occur in the breast, chest, shoulder, pelvis, groin, genitals, or face tissues.

Swelling ranges from mild, hardly noticeable changes in the size of the arm or leg to extreme swelling that can restricted range of motion in the joints or even make it impossible to use the affected limb.

Other symptoms of lymphedema include tissue changes, such as a hardening and thickening of the skin (fibrosis); skin discoloration; pain and altered sensation; and limb heaviness or tightness.

Clinically, the Stemmer sign is a very important component in diagnosing lymphedema. Basically, the Stemmer sign is a test where one pinches or lifts the skin (using the thumb and index finger) over a bony prominence of the foot, such as the base of the second toe. If the skin is difficult to pinch together and cannot be lifted up, or "tented," the Stemmer sign is positive and lymphedema is present.

In patients with chronic venous insufficiency, clinical and laboratory evidence will confirm the presence of microangiopathy (a disease of the blood vessels causing them to "leak" protein) in the lymphatic network.

Managing lymphedema

Kirsten Twaite is a physical therapist and a Certified Lymphedema Therapist (CLT) at Jade Integrated Health in Portland and Brunswick, Maine. When she evaluates a patient's swelling, she considers whether it's a lymph transport or overload issue, but, said Twaite, "from my perspective as a physical therapist, it almost doesn't matter where the defect is coming from, as long as we're effectively managing it."

Since there is no cure for the chronic condition of lymphedema, management remains the best tool for treating patients. Treatment modalities for managing the lymphedema include surgery, as well as skin care, compression garments, compression pumps, manual lymphatic drainage, exercises, and, most importantly, patient education.

A CLT helps the patient's body move fluid from the interstitium into the lymphatic system, on its way back to the circulatory system using a combination of evidence-based interventions is known as Complete Decongestive Therapy (CDT), or Complex Decongestive Therapy, in the US and Decongestive Lymphatic Therapy (DLT) internationally.

CDT is made up of four components of care:
1. Manual lymphatic drainage (MLD)
2. Static compression and bandaging
3. Skin hygiene
4. Appropriate exercise program

MLD is a very systematic light massage in order to increase the pulse of the lymphatic system. Twaite says that she's "not pushing the fluid anywhere, but rather asking the body to work harder to move that fluid to where it belongs." Twaite points out that MLD does not increase the pulse permanently - only for the time she's working on the patient. Then it's time to utilize compression bandaging. The compression prevents the fluid from refilling, but the type and level of compression bandaging depends upon the location and severity of the swelling. The process is often repeated a few times over the course of several days with the goal of making the limb smaller and less swollen before fitting the patient for a compression garment.

In the past, short stretch bandages were the only option for inelastic compression. Due to innovations in compression, however, there are now more options. Static compression with adjustable Velcro wraps, for example, makes it much easier for patients to comply.

Concurrent with these components is working with the patient to learn an appropriate exercise program. Movement increases the lymphatic pump while also helping to gently strengthen the limb. Depending on the patient, the home exercise program will contain a walking program, or possibly movement in a pool; the latter is especially good for patients who have mobility issues.

Finally, maintaining good skin hygiene keeps the skin on the swollen limb clean and infection-free. Twaite teaches patients how to gently wash the skin, keep the skin hydrated to guard from cracking, and promptly care for traumatic breaks in the skin that might occur.

Twaite considers lymphedema management to be a priority so that people with the condition can live independently and enjoy a good quality of life. "We don't have a cure for lymphedema, but if we can get ahead of it before it affects a person's mobility, we can manage it so much more efficiently," said Twaite. "Their ability to move, exercise, and participate in their community the way they want to is a huge motivator for me."


RESOURCES

  • Lymphedema Comorbidities and Treatment Rate in the United States Son, Andrew et al J Vasc Surg Venous Lymphat Disord [2019 Sep;7(5):724-730]
  • Structure and Distribution of an Unrecognized Interstitium in Human Tissues Benias, P.C., Wells, R.G., Sackey-Aboagye, B. et al. Sci Rep 8, 4947 [March 2018]

Vein Tech

Flexitouch Plus System

By Benjamin Lee

Lymphedema is a chronic and progressive condition in which damage to the lymphatic system causes a buildup of lymph fluid in body tissues. There is no cure for lymphedema, but there are ways that patients can manage their symptoms and minimize their risk of infection.

One management modality is the intermittent pneumatic compression device, also known as a pneumatic pump. The Flexitouch Plus system by Tactile Medical consists of a garment that wraps around the affected area and held in place by Velcro closures. The garment works by sequentially inflating and deflating its chambers to create a gentle wave-like motion that stimulates the flow of lymph from the impaired area toward healthy regions of the body where it is absorbed and processed. The garment is attached to a small computer that controls up to three different treatment programs or sequences.

According to Ben Scarborough, Associate Product Specialist at Tactile Medical, there are garments available for every extremity, including the head and neck. "Any part that can swell, we have the ability to alleviate the discomfort at that site." Scarborough has found that in vein practices, patients with venous ulcers, chronic vein insufficiency, venous hypertension, and lymphedema in the lower limbs are the most common, while lymphedema clinics will see patients present with swelling in other extremities as well.

A pneumatic pump is used by some treatment facilities as part of a professional service, though there are patients who use them at home. The Flexitouch Plus system is only available with a prescription through a clinician, such as a primary care physician or vein specialist. The cost to a patient varies greatly depending on the patient's insurance plan.

Once a patient receives the device, the company makes sure that the patient has been properly trained to use it. If any pneumatic pump is not used properly, it can force excess fluids into the surrounding tissues and create more problems, so Tactile Medical provides patients with how-to DVDs, videos on YouTube, information on their website, and follow-up inquiries with the patient.

"Once the therapist or doctor establishes the patient's specific treatment, it arrives to the patient with the program already in the compressor's computer, plus the garments are quite easy to put on and take off," said Scarborough. Just as with all other forms of lymphedema treatment, patients should work closely with their physical therapist to be sure they are using the device correctly. Scarborough adds that the patient should never make therapeutic changes without first asking their clinician.

Once a person is diagnosed with lymphedema, it never goes away - and it's a progressive disease. Scarborough emphasizes that one should try to get the condition diagnosed as soon as possible so treatment can start in the earliest stages when the patient can more effectively manage it. If someone is diagnosed and treated at stage one, for example, then it's possible to treat and keep it at stage one for years. If treatment begins at stage three, however, then the likelihood of cellulitis, fibrosis, or open ulcers make treatment much more difficult.

"Whatever the stage, our end goal is to reduce swelling and improve the patient's quality of life," said Scarborough. "If we can make the pain tolerable or even non-existent, then they can return to living their lives the way they did before."

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